Pulmonary Hypertension


Pulmonary Hypertension…..https://www.ipage.com/controlpanel/domaincentral/3.0/

Pulmonary hypertension begins when tiny arteries in the lungs, called pulmonary arteries, and capillaries become narrowed, blocked or destroyed. This makes it harder for blood to flow through your lungs, and raises pressure within your lungs' arteries. As the pressure builds, your heart's lower right chamber (right ventricle) must work harder to pump blood through your lungs, eventually causing your heart muscle to weaken and eventually fail.

Pulmonary Hypertension affects the lungs and the heart: the blood vessels in the lungs are constricted, and the right heart (RV, right ventricle) becomes enlarged.  


The current "gold standard" of diagnosing PH is a highly invasive process called right heart catheterization, and involves snaking a catheter through an artery into the right side of the heart to measure the pressure.  Because PH symptoms are so similar to other conditions, it is often only diagnosed  when symptoms become severe.  PH is very heterogenious, can occur on its own (idiopathic, heritable forms), or associated with many different diseases.  Some infectious diseases caused by parasites, for example Schistosomiasis in humans or heart-worm disease in dogs and cats, can give rise to pulmonary hypertension.  High altitude, in humans and cattle, and racing can also cause pulmonary hypertension.

Mirna Analytics will serve to add on to this "gold standard" with our miRNA signatures to aid in early diagnosis, sub typing, following of disease progression. 

© Mirna Analytics 2016